10. '50/50'

A comedy about cancer is a huge risk. Based liberally on writer Will Reiser’s own experience with the disease, '50/50' takes the viewer on Joseph Gordon-Levitt’s wild ride of emotions that range anywhere from elation to desperation. Seth Rogen provides the comic relief to what, in essence, is a heartbreaking look at the very real horrors of a cancer diagnosis. -- M.R.