John Malkovich and Michelle Pfeiffer

... Michelle Pfeiffer, who went on to earn her first Oscar nomination for 1988's ‘Dangerous Liaisons’; in that role, she is seduced by John Malkovich’s lothario character. Ironically, Malkovich and Pfeiffer reportedly had a real-life affair during filming, which ended his marriage to actress Glenne Headly. Malkovich, co-star Glenn Close, and director Stephen Frears later re-united for 'Mary Reilly' with Julia Roberts, who had just starred in ‘Something to Talk About,’ which featured a cheating husband played by Dennis Quaid, who in reality was married to ...