'50/50' (2011)

Song: "Yellow Ledbetter" by Pearl Jam
Why We Love It: It isn't classic like some of the others on here, but closing the wonderful cancer dramedy '50/50' with Pearl Jam was one of the best musical decisions of 2011. As producer and star Seth Rogen said, "Every time I hear that song, I see a pile of money in flames." It was worth it.