Dey has three features to his name: Shanghai Noon, Showtime, and Failure to Launch. That should give you an idea of the tone of this adaptation, and since Garfield was CG, I'd bet my bottom dollar that Marmaduke will follow the trend. However, as of right now THR says that it hasn't been decided whether the famous dog will be "live-action, animated, or a mutt."
Now for your Marmaduke-ignorant people out there: He's a Great Dane comically created back in the '50s who lives with the Winslow family and goes by his own set of mischievous rules.
Considering the horrors of projects like Garfield, The Chipmunks, and The Cat in the Hat, I'm 100% not keen on this idea. That being said, at least they're not taking my beloved comic ... yet. Hollywood, I'm warning you right now: If you make a crappy Calvin and Hobbes feature film, the voodoo dolls are coming out.